| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50123470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90576 (CHEMBL701160) |
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| IC50 | 370±n/a nM |
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| Citation |  Zhuang, L; Wai, JS; Embrey, MW; Fisher, TE; Egbertson, MS; Payne, LS; Guare, JP; Vacca, JP; Hazuda, DJ; Felock, PJ; Wolfe, AL; Stillmock, KA; Witmer, MV; Moyer, G; Schleif, WA; Gabryelski, LJ; Leonard, YM; Lynch, JJ; Michelson, SR; Young, SD Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells. J Med Chem46:453-6 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50123470 |
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| n/a |
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| Name | BDBM50123470 |
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| Synonyms: | (3-Benzyl-phenyl)-(8-hydroxy-quinolin-7-yl)-methanone | (3-benzylphenyl)(8-hydroxyquinolin-7-yl)methanone | 7-(3-benzylbenzoyl)quinolin-8-ol (Compound 7) | CHEMBL35842 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17NO2 |
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| Mol. Mass. | 339.3866 |
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| SMILES | Oc1c(ccc2cccnc12)C(=O)c1cccc(Cc2ccccc2)c1 |
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| Structure | 
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