Reaction Details |
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Target | 5-hydroxytryptamine receptor 7 |
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Ligand | BDBM50123696 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_3751 (CHEMBL620752) |
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Ki | >800±n/a nM |
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Citation | Perrone, R; Berardi, F; Colabufo, NA; Lacivita, E; Leopoldo, M; Tortorella, V Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands. J Med Chem46:646-9 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 7 |
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Name: | 5-hydroxytryptamine receptor 7 |
Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 49852.62 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cloned 5-HT7R. |
Residue: | 448 |
Sequence: | MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT
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BDBM50123696 |
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n/a |
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Name | BDBM50123696 |
Synonyms: | 6-(4-Cyclohexyl-piperazin-1-yl)-1-(2-hydroxy-phenyl)-hexan-1-one | CHEMBL155916 |
Type | Small organic molecule |
Emp. Form. | C22H34N2O2 |
Mol. Mass. | 358.5176 |
SMILES | Oc1ccccc1C(=O)CCCCCN1CCN(CC1)C1CCCCC1 |
Structure |
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