Ki Summary

Reaction Details

Report a problem with these data

Target

Nuclear factor NF-kappa-B p105 subunit

Ligand

BDBM50561592

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2075371 (CHEMBL4730905)

216±n/a nM

Citation

Annand, JR; Henderson, AR; Cole, KS; Maurais, AJ; Becerra, J; Liu, Y; Weerapana, E; Koehler, AN; Mapp, AK; Schindler, CS Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKK?. ACS Med Chem Lett11:1913-1918 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nuclear factor NF-kappa-B p105 subunit

Name:

Nuclear factor NF-kappa-B p105 subunit

Synonyms:

NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit

Type:

Protein

Mol. Mass.:

105329.57

Organism:

Homo sapiens (Human)

Description:

P19838

Residue:

968

Sequence:

MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI

BDBM50561592

n/a

Name

BDBM50561592

Synonyms:

(+)-Gibberellic Acid | CHEBI:28833 | GIBBERELLIN A3

Type

Small organic molecule

Emp. Form.

C19H22O6

Mol. Mass.

346.3744

SMILES

[H][C@@]12CC[C@]3(O)C[C@]1(CC3=C)[C@@H](C(O)=O)[C@]1([H])[C@@]3(C)[C@@H](O)C=C[C@@]21OC3=O |r,wU:11.13,7.8,19.21,1.0,15.17,wD:4.4,23.27,17.19,c:23,TLB:20:19:15:24.25,THB:11:15:22.21.19:24.25,26:25:15:22.21.19,10:9:6:3.2.1,(.84,2.43,;.75,.58,;2.26,1.18,;3.44,.1,;3.11,-1.46,;4.56,-1.96,;1.77,-1.17,;.46,-1.03,;.82,-2.65,;2.42,-2.9,;3.13,-4.25,;-1.09,-1.15,;-1.86,-2.47,;-1.11,-3.8,;-3.39,-2.46,;-1.75,.24,;.07,.57,;-1.64,1.56,;-2.65,.41,;-2.61,2.98,;-4.12,3.15,;-1.48,4.02,;-1.62,2.79,;-.63,1.28,;1,1.21,;-.22,1.78,;0,3.29,)|

Structure