| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM50301021 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2075821 (CHEMBL4731355) |
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| Ki | 2.0±n/a nM |
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| Citation |  Shanu-Wilson, J; Evans, L; Wrigley, S; Steele, J; Atherton, J; Boer, J Biotransformation: Impact and Application of Metabolism in Drug Discovery. ACS Med Chem Lett11:2087-2107 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55689.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q01827 |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50301021 |
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| n/a |
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| Name | BDBM50301021 |
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| Synonyms: | (+)-dihydrotetrabenzaine | CHEMBL576222 | US11053242, Compound R,R,R-DHTBZ |
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| Type | Small organic molecule |
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| Emp. Form. | C19H29NO3 |
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| Mol. Mass. | 319.4385 |
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| SMILES | COc1cc2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3c2cc1OC |r| |
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| Structure | 
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