| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein |
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| Ligand | BDBM50409787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_220754 (CHEMBL841914) |
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| IC50 | 18000±n/a nM |
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| Citation |  Parkes, KE; Ermert, P; Fässler, J; Ives, J; Martin, JA; Merrett, JH; Obrecht, D; Williams, G; Klumpp, K Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem46:1153-64 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein |
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| Name: | Polymerase acidic protein |
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| Synonyms: | PA | PA_INBLE | RNA-directed RNA polymerase subunit P2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83123.24 |
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| Organism: | Influenza B virus (B/Lee/40) |
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| Description: | ChEMBL_220754 |
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| Residue: | 726 |
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| Sequence: | MDTFITKNFQTTIIQKAKNTMAEFSEDPELQPAVLFNICVHLEVCYVISDMNFLDEEGKT
YTALEGQGKEQNLRPQYEVIEGMPRNIAWMVQRSLAQEHGIETPRYLADLFDYKTKRFIE
VGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSDESSLDEEGKGRVLSRLTELQAE
LSLKNLWQVLIGEEEIEKGIDFKLGQTISKLRNISVPAGFSNFEGMRSYIDNIDPKGAIE
RNLARMSPLVSVTPKKLKWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSK
KPKTLAKECLERYSTLRDQTDPILIMKSEKANENFLWRLWRDCVNTISNEETGNELQKTN
YAKWATGDGLTYQKIMKEVAIDDETMYQEEPKIPNKCRVAAWVQAEMNLLSTLTSKRALD
LPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHTSLLNESNASMGKYKVIP
ITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFK
IGSLFVSGREKPVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVDQESSIQGYDMT
KACFKGDRVNNPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRR
LLLLIQALKDRKGPWVFDLEGMYFGVEECISNNPWVIQSAYWFNEWLGIEKEGSKVLESI
DEIMDE
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| BDBM50409787 |
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| n/a |
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| Name | BDBM50409787 |
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| Synonyms: | CHEMBL16377 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16N2O4 |
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| Mol. Mass. | 360.3627 |
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| SMILES | CC(=O)c1c(O)n(O)c2cc(NC(=O)c3ccc4ccccc4c3)ccc12 |
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| Structure | 
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