| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50126486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212866 |
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| Ki | 6100±n/a nM |
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| Citation |  Sanderson, PE; Cutrona, KJ; Savage, KL; Naylor-Olsen, AM; Bickel, DJ; Bohn, DL; Clayton, FC; Krueger, JA; Lewis, SD; Lucas, BJ; Lyle, EA; Wallace, AA; Welsh, DC; Yan, Y 3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors. Bioorg Med Chem Lett13:1441-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50126486 |
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| n/a |
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| Name | BDBM50126486 |
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| Synonyms: | CHEMBL32549 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(2-cyclopropylmethyl-7-methyl-1,1,5-trioxo-1,3,4,5-tetrahydro-2H-1lambda*6*-thia-2,4,6-triaza-naphthalen-6-yl)-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N6O4S |
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| Mol. Mass. | 446.523 |
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| SMILES | Cc1cc2c(NCN(CC3CC3)S2(=O)=O)c(=O)n1CC(=O)NCc1ccc(N)nc1C |
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| Structure | 
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