| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
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| Ligand | BDBM50563245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2081755 (CHEMBL4737546) |
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| EC50 | 64±n/a nM |
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| Citation |  Kent, CN; Fulton, MG; Stillwell, KJ; Dickerson, JW; Loch, MT; Rodriguez, AL; Blobaum, AL; Boutaud, O; Rook, JL; Niswender, CM; Conn, PJ; Lindsley, CW Discovery and optimization of a novel CNS penetrant series of mGlu Bioorg Med Chem Lett37:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 4 |
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| Name: | Metabotropic glutamate receptor 4 |
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| Synonyms: | GRM4_RAT | Gprc1d | Grm4 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 4 (mGlu4) | Mglur4 | mGlu4 | metabotropic glutamate 4 | metabotropic glutamate 4a |
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| Type: | Enzyme |
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| Mol. Mass.: | 101849.79 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31423 |
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| Residue: | 912 |
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| Sequence: | MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQ
KSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIA
ATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALAT
KQTYVTYTNHAI
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| BDBM50563245 |
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| n/a |
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| Name | BDBM50563245 |
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| Synonyms: | CHEMBL4743836 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12BrClN2O2S |
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| Mol. Mass. | 363.658 |
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| SMILES | Clc1cc(Br)cc(NC(=O)[C@H]2CSCCC(=O)N2)c1 |r| |
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| Structure | 
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