| Reaction Details |
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 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 3 |
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| Ligand | BDBM50563551 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2083233 (CHEMBL4739024) |
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| IC50 | 720±n/a nM |
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| Citation |  N?mec, V; Maier, L; Berger, BT; Chaikuad, A; Drápela, S; Sou?ek, K; Knapp, S; Paruch, K Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur J Med Chem215:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeodomain-interacting protein kinase 3 |
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| Name: | Homeodomain-interacting protein kinase 3 |
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| Synonyms: | DYRK6 | FIST3 | HIPK3 | HIPK3_HUMAN | PKY |
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| Type: | PROTEIN |
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| Mol. Mass.: | 133763.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774503 |
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| Residue: | 1215 |
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| Sequence: | MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP
GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
GFPLSPTKLSQYPYM
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| BDBM50563551 |
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| n/a |
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| Name | BDBM50563551 |
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| Synonyms: | CHEMBL4777533 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N5O |
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| Mol. Mass. | 319.3605 |
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| SMILES | CC(C)(C)c1ccc(cc1)-c1coc2ccc(nc12)-c1nn[nH]n1 |
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| Structure | 
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