| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50127760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64198 |
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| Ki | 2±n/a nM |
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| Citation |  Lange, UE; Braje, WM; Amberg, W; Kettschau, G Solid-phase synthesis of endothelin receptor antagonists. Bioorg Med Chem Lett13:1721-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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|
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| BDBM50127760 |
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| n/a |
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| Name | BDBM50127760 |
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| Synonyms: | 2-[4-(4-Ethoxy-phenyl)-6-methyl-pyrimidin-2-yloxy]-3,3-diphenyl-butyric acid | CHEMBL46311 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28N2O4 |
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| Mol. Mass. | 468.5436 |
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| SMILES | CCOc1ccc(cc1)-c1cc(C)nc(OC(C(O)=O)C(C)(c2ccccc2)c2ccccc2)n1 |
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| Structure | 
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