| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 2 |
|---|
| Ligand | BDBM50563780 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2084262 (CHEMBL4765525) |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Beesu, M; Caruso, G; Salyer, AC; Shukla, NM; Khetani, KK; Smith, LJ; Fox, LM; Tanji, H; Ohto, U; Shimizu, T; David, SA Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. J Med Chem59:3311-30 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 2 |
|---|
| Name: | Toll-like receptor 2 |
|---|
| Synonyms: | TIL4 | TLR2 | TLR2_HUMAN | Toll-like receptor 2 | Toll-like receptor 2 (TLR2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 89837.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60603 |
|---|
| Residue: | 784 |
|---|
| Sequence: | MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
AIKS
|
|
|
|---|
| BDBM50563780 |
|---|
| n/a |
|---|
| Name | BDBM50563780 |
|---|
| Synonyms: | CHEMBL4795714 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26ClN3O |
|---|
| Mol. Mass. | 371.904 |
|---|
| SMILES | Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
