| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 8 |
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| Ligand | BDBM50563780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2084290 (CHEMBL4765553) |
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| IC50 | 8060±n/a nM |
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| Citation |  Beesu, M; Caruso, G; Salyer, AC; Shukla, NM; Khetani, KK; Smith, LJ; Fox, LM; Tanji, H; Ohto, U; Shimizu, T; David, SA Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. J Med Chem59:3311-30 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 8 |
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| Name: | Toll-like receptor 8 |
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| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119828.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR97 |
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| Residue: | 1041 |
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| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
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| BDBM50563780 |
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| n/a |
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| Name | BDBM50563780 |
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| Synonyms: | CHEMBL4795714 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26ClN3O |
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| Mol. Mass. | 371.904 |
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| SMILES | Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1 |
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| Structure | 
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