Ki Summary

Reaction Details

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Target

Lanosterol synthase

Ligand

BDBM50128045

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_148897 (CHEMBL754981)

IC50

610±n/a nM

Citation

Lenhart, A; Reinert, DJ; Aebi, JD; Dehmlow, H; Morand, OH; Schulz, GE Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem46:2083-92 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Lanosterol synthase

Name:

Lanosterol synthase

Synonyms:

2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase

Type:

PROTEIN

Mol. Mass.:

83309.32

Organism:

Homo sapiens (Human)

Description:

ChEMBL_11231

Residue:

732

Sequence:

MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP

BDBM50128045

n/a

Name

BDBM50128045

Synonyms:

ALLYL-{6-[3-(4-BROMO-PHENYL)-BENZOFURAN-6-YLOXY]-HEXYL-}-METHYL-AMIN | Allyl-{6-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-hexyl}-methyl-amine | CHEMBL445353 | N-allyl-6-(3-(4-bromophenyl)benzofuran-6-yloxy)-N-methylhexan-1-aminium

Type

Small organic molecule

Emp. Form.

C24H28BrNO2

Mol. Mass.

442.389

SMILES

CN(CCCCCCOc1ccc2c(coc2c1)-c1ccc(Br)cc1)CC=C

Structure