Ki Summary

Reaction Details

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Target

Lanosterol synthase

Ligand

BDBM50128048

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_148897 (CHEMBL754981)

IC50

98±n/a nM

Citation

Lenhart, A; Reinert, DJ; Aebi, JD; Dehmlow, H; Morand, OH; Schulz, GE Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem46:2083-92 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Lanosterol synthase

Name:

Lanosterol synthase

Synonyms:

2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase

Type:

PROTEIN

Mol. Mass.:

83309.32

Organism:

Homo sapiens (Human)

Description:

ChEMBL_11231

Residue:

732

Sequence:

MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP

BDBM50128048

n/a

Name

BDBM50128048

Synonyms:

(4-Bromo-phenyl)-{4-[6-(cyclopropyl-methyl-amino)-hexyloxy]-2-fluoro-phenyl}-methanone | (6-(4-(4-bromobenzoyl)-3-fluorophenoxy)hexyl)-N-methylcyclopropanaminium | CHEMBL292514 | N-(6-(4-(4-bromobenzoyl)-3-fluorophenoxy)hexyl)-N-methylcyclopropanaminium

Type

Small organic molecule

Emp. Form.

C23H27BrFNO2

Mol. Mass.

448.368

SMILES

CN(CCCCCCOc1ccc(C(=O)c2ccc(Br)cc2)c(F)c1)C1CC1

Structure