Reaction Details |
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Target | Lanosterol synthase |
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Ligand | BDBM50128052 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148897 (CHEMBL754981) |
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IC50 | 1900±n/a nM |
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Citation | Lenhart, A; Reinert, DJ; Aebi, JD; Dehmlow, H; Morand, OH; Schulz, GE Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem46:2083-92 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lanosterol synthase |
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Name: | Lanosterol synthase |
Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
Type: | PROTEIN |
Mol. Mass.: | 83309.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_11231 |
Residue: | 732 |
Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
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BDBM50128052 |
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n/a |
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Name | BDBM50128052 |
Synonyms: | Allyl-{6-[4-(6-bromo-benzo[d]isothiazol-3-yl)-phenoxy]-hexyl}-methyl-amine | CHEMBL112553 | CHEMBL294809 | N-allyl-6-(4-(6-bromobenzo[d]isothiazol-3-yl)phenoxy)-N-methylhexan-1-aminium | N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE |
Type | Small organic molecule |
Emp. Form. | C23H27BrN2OS |
Mol. Mass. | 459.442 |
SMILES | CN(CCCCCCOc1ccc(cc1)-c1nsc2cc(Br)ccc12)CC=C |
Structure |
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