Ki Summary

Reaction Details

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Target

Lanosterol synthase

Ligand

BDBM50128070

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_148897 (CHEMBL754981)

IC50

16±n/a nM

Citation

Lenhart, A; Reinert, DJ; Aebi, JD; Dehmlow, H; Morand, OH; Schulz, GE Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem46:2083-92 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Lanosterol synthase

Name:

Lanosterol synthase

Synonyms:

2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase

Type:

PROTEIN

Mol. Mass.:

83309.32

Organism:

Homo sapiens (Human)

Description:

ChEMBL_11231

Residue:

732

Sequence:

MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP

BDBM50128070

n/a

Name

BDBM50128070

Synonyms:

(4''-{[ALLYL(METHYL)AMINO]METHYL}-1,1''-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE | CHEMBL481608 | CHEMBL65230 | {4'-[(Allyl-methyl-amino)-methyl]-biphenyl-4-yl}-(4-bromo-phenyl)-methanone

Type

Small organic molecule

Emp. Form.

C24H22BrNO

Mol. Mass.

420.342

SMILES

CN(CC=C)Cc1ccc(cc1)-c1ccc(cc1)C(=O)c1ccc(Br)cc1

Structure