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TargetSqualene--hopene cyclase
LigandBDBM50128061
Substrate/Competitorn/a
Meas. Tech.ChEMBL_201950 (CHEMBL809137)
IC50 62±n/a nM
Citation Lenhart, AReinert, DJAebi, JDDehmlow, HMorand, OHSchulz, GE Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J Med Chem46:2083-92 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Squalene--hopene cyclase
Name:Squalene--hopene cyclase
Synonyms:SQHC_ALIAD | Squalene--hopene cyclase | Squalene-hopene cyclase | shc
Type:PROTEIN
Mol. Mass.:71559.28
Organism:Alicyclobacillus acidocaldarius
Description:ChEMBL_201951
Residue:631
Sequence:
MAEQLVEAPAYARTLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILDRVDRDR
MEKIRRYLLHEQREDGTWALYPGGPPDLDTTIEAYVALKYIGMSRDEEPMQKALRFIQSQ
GGIESSRVFTRMWLALVGEYPWEKVPMVPPEIMFLGKRMPLNIYEFGSWARATVVALSIV
MSRQPVFPLPERARVPELYETDVPPRRRGAKGGGGWIFDALDRALHGYQKLSVHPFRRAA
EIRALDWLLERQAGDGSWGGIQPPWFYALIALKILDMTQHPAFIKGWEGLELYGVELDYG
GWMFQASISPVWDTGLAVLALRAAGLPADHDRLVKAGEWLLDRQITVPGDWAVKRPNLKP
GGFAFQFDNVYYPDVDDTAVVVWALNTLRLPDERRRRDAMTKGFRWIVGMQSSNGGWGAY
DVDNTSDLPNHIPFCDFGEVTDPPSEDVTAHVLECFGSFGYDDAWKVIRRAVEYLKREQK
PDGSWFGRWGVNYLYGTGAVVSALKAVGIDTREPYIQKALDWVEQHQNPDGGWGEDCRSY
EDPAYAGKGASTPSQTAWALMALIAGGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTG
FPGDFYLGYTMYRHVFPTLALGRYKQAIERR
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  Blast E-value cutoff:
BDBM50128061
n/a
NameBDBM50128061
Synonyms:(4-Bromo-phenyl)-(4-{2-[(cyclopropyl-methyl-amino)-methyl]-cyclopropylmethoxy}-phenyl)-methanone | CHEMBL63522 | N-(((1S,2S)-2-((4-(4-bromobenzoyl)phenoxy)methyl)cyclopropyl)methyl)-N-methylcyclopropanaminium
TypeSmall organic molecule
Emp. Form.C22H24BrNO2
Mol. Mass.414.335
SMILESCN(C[C@H]1C[C@@H]1COc1ccc(cc1)C(=O)c1ccc(Br)cc1)C1CC1
Structure
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