| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 3 |
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| Ligand | BDBM50564011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2086314 (CHEMBL4767577) |
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| IC50 | 1660±n/a nM |
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| Citation |  Zar?ba, P; Gryz?o, B; Malawska, K; Sa?at, K; Höfner, GC; Nowaczyk, A; Fija?kowski, ?; Rapacz, A; Podkowa, A; Furga?a, A; ?mudzki, P; Wanner, KT; Malawska, B; Kulig, K Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem188:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 3 |
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| Name: | Sodium- and chloride-dependent GABA transporter 3 |
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| Synonyms: | GABA transporter | GAT-3 | Gabt3 | Gabt4 | Gat-4 | Gat3 | Gat4 | S6A11_MOUSE | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Sodium- and chloride-dependent GABA transporter 4 | Solute carrier family 6 member 11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69962.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460090 |
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| Residue: | 627 |
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| Sequence: | MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAG
EIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRV
CPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQK
LNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWK
GTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQ
IFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV
PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDM
YPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECV
CIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYT
YPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPR
TVTVNDCEAKVKGDGTISAITEKETHF
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| BDBM50564011 |
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| n/a |
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| Name | BDBM50564011 |
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| Synonyms: | CHEMBL4779064 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37NO6 |
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| Mol. Mass. | 519.6286 |
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| SMILES | COc1ccc(cc1)C(OCCN1CCC[C@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C |r| |
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| Structure | 
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