| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 5 |
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| Ligand | BDBM50128205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31884 (CHEMBL645674) |
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| IC50 | 13600±n/a nM |
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| Citation |  Levy, DE; Bao, M; Cherbavaz, DB; Tomlinson, JE; Sedlock, DM; Homcy, CJ; Scarborough, RM Metal coordination-based inhibitors of adenylyl cyclase: novel potent P-site antagonists. J Med Chem46:2177-86 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 5 |
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| Name: | Adenylate cyclase type 5 |
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| Synonyms: | ADCY5 | ADCY5_HUMAN | Adenylate cyclase | Adenylate cyclase type V |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138919.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_31732 |
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| Residue: | 1261 |
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| Sequence: | MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
S
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| BDBM50128205 |
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| n/a |
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| Name | BDBM50128205 |
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| Synonyms: | 2-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyloxy]-N-hydroxy-acetamide | CHEMBL308914 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N6O3 |
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| Mol. Mass. | 290.278 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1C[C@@H](OCC(=O)NO)C=C1 |c:21| |
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| Structure | 
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