| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 2 |
|---|
| Ligand | BDBM50128264 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_90288 (CHEMBL697507) |
|---|
| Ki | 370±n/a nM |
|---|
| Citation |  Bjerrum, EJ; Kristensen, AS; Pickering, DS; Greenwood, JR; Nielsen, B; Liljefors, T; Schousboe, A; Bräuner-Osborne, H; Madsen, U Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem46:2246-9 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor 2 |
|---|
| Name: | Glutamate receptor 2 |
|---|
| Synonyms: | AMPA-selective glutamate receptor 2 | GLUR2 | GRIA2 | GRIA2_HUMAN | GluR-2 | GluR-B | GluR-K2 | Glutamate AMPA 2 | Glutamate receptor 2 | Glutamate receptor AMPA 1/2 | Glutamate receptor AMPA 2/3 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 98825.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glutamate AMPA 2 GRIA2 HUMAN::P42262 |
|---|
| Residue: | 883 |
|---|
| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
|
|
|
|---|
| BDBM50128264 |
|---|
| n/a |
|---|
| Name | BDBM50128264 |
|---|
| Synonyms: | (R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionate | 2-Amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)-propionic acid | CHEMBL72366 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H7ClN2O4 |
|---|
| Mol. Mass. | 206.584 |
|---|
| SMILES | NC(Cc1o[nH]c(=O)c1Cl)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
