| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C alpha type |
|---|
| Ligand | BDBM50128287 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_160102 |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Faul, MM; Gillig, JR; Jirousek, MR; Ballas, LM; Schotten, T; Kahl, A; Mohr, M Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett13:1857-9 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C alpha type |
|---|
| Name: | Protein kinase C alpha type |
|---|
| Synonyms: | KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76755.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
|---|
| Residue: | 672 |
|---|
| Sequence: | MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
|
|
|
|---|
| BDBM50128287 |
|---|
| n/a |
|---|
| Name | BDBM50128287 |
|---|
| Synonyms: | 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | CHEMBL53596 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H26N4O2 |
|---|
| Mol. Mass. | 438.5209 |
|---|
| SMILES | CN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
