| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-like growth factor-binding protein 3 |
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| Ligand | BDBM50128436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_90404 |
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| Ki | 32±n/a nM |
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| Citation |  Zhu, YF; Wilcoxen, K; Gross, T; Connors, P; Strack, N; Gross, R; Huang, CQ; McCarthy, JR; Xie, Q; Ling, N; Chen, C 6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain. Bioorg Med Chem Lett13:1927-30 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-like growth factor-binding protein 3 |
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| Name: | Insulin-like growth factor-binding protein 3 |
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| Synonyms: | IBP3 | IBP3_HUMAN | IGFBP3 | Insulin-like growth factor binding protein 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31690.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_90404 |
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| Residue: | 291 |
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| Sequence: | MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
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| BDBM50128436 |
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| n/a |
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| Name | BDBM50128436 |
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| Synonyms: | 1-[4-(Biphenyl-4-yloxy)-3-fluoro-benzoyl]-6,7-dihydroxy-isoquinoline-3-carboxylic acid | CHEMBL57084 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H18FNO6 |
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| Mol. Mass. | 495.4547 |
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| SMILES | OC(=O)c1cc2cc(O)c(O)cc2c(n1)C(=O)c1ccc(Oc2ccc(cc2)-c2ccccc2)c(F)c1 |
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| Structure | 
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