| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha |
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| Ligand | BDBM50564381 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2087619 (CHEMBL4768882) |
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| IC50 | 360±n/a nM |
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| Citation |  Dalle Vedove, A; Zonta, F; Zanforlin, E; Demitri, N; Ribaudo, G; Cazzanelli, G; Ongaro, A; Sarno, S; Zagotto, G; Battistutta, R; Ruzzene, M; Lolli, G A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem195:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha |
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| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 45151.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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| BDBM50564381 |
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| n/a |
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| Name | BDBM50564381 |
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| Synonyms: | CHEMBL4778120 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4O3S |
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| Mol. Mass. | 358.415 |
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| SMILES | COc1cc(\C=C(/C#N)C(=O)Nc2nnc(s2)C(C)(C)C)ccc1O |
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| Structure | 
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