| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50564418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2087676 (CHEMBL4768939) |
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| Ki | 19500±n/a nM |
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| Citation |  Kamchonwongpaisan, S; Charoensetakul, N; Srisuwannaket, C; Taweechai, S; Rattanajak, R; Vanichtanankul, J; Vitsupakorn, D; Arwon, U; Thongpanchang, C; Tarnchompoo, B; Vilaivan, T; Yuthavong, Y Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities. Eur J Med Chem195:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50564418 |
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| n/a |
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| Name | BDBM50564418 |
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| Synonyms: | CHEMBL4792349 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18BrCl2N5O2 |
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| Mol. Mass. | 427.124 |
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| SMILES | Br.CC1N=C(N)N=C(N)N1OCCCOc1cccc(Cl)c1Cl |t:2,5| |
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| Structure | 
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