Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM50564768 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2089125 (CHEMBL4770388) |
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Kd | 337±n/a nM |
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Citation | Cao, DS; Jiang, SL; Guan, YD; Chen, XS; Zhang, LX; Zhang, Y; Chen, AF; Yang, JM; Cheng, Y A multi-scale systems pharmacology approach uncovers the anti-cancer molecular mechanism of Ixabepilone. Eur J Med Chem199:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM50564768 |
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n/a |
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Name | BDBM50564768 |
Synonyms: | Azaepothilone b | BMS 247550-01 | BMS-247550 | BMS-247550-01 | CHEBI:63605 | Ixabepilone | Ixempra | Ixempra kit | NSC-747973 |
Type | Small organic molecule |
Emp. Form. | C27H42N2O5S |
Mol. Mass. | 506.698 |
SMILES | [H][C@]12C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC[C@@]1(C)O2)C(\C)=C\c1csc(C)n1 |r| |
Structure |
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