| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
|---|
| Ligand | BDBM50129499 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_157989 |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Rao, PN; Amini, M; Li, H; Habeeb, AG; Knaus, EE 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett13:2205-9 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 2 |
|---|
| Name: | Prostaglandin G/H synthase 2 |
|---|
| Synonyms: | COX2 | Cyclooxygenase-1 (COX-1) | Cyclooxygenase-2 (COX-2) | PGH2_SHEEP | PTGS2 | Prostaglandin G/H synthase (Cyclooxygenase-2) | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68976.98 |
|---|
| Organism: | Ovis aries (Sheep) |
|---|
| Description: | n/a |
|---|
| Residue: | 603 |
|---|
| Sequence: | MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLT
RIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYS
YKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTN
LMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQ
MINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDV
LKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQN
RIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVA
GRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALY
GDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVG
FKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERS
TEL
|
|
|
|---|
| BDBM50129499 |
|---|
| n/a |
|---|
| Name | BDBM50129499 |
|---|
| Synonyms: | 6-Isopropyl-3-(4-methanesulfonyl-phenyl)-4-phenyl-pyran-2-one | CHEMBL305282 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20O4S |
|---|
| Mol. Mass. | 368.446 |
|---|
| SMILES | CC(C)c1cc(-c2ccccc2)c(-c2ccc(cc2)S(C)(=O)=O)c(=O)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
