| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Activin receptor type-1 |
|---|
| Ligand | BDBM50564975 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2089821 (CHEMBL4771084) |
|---|
| IC50 | 5.0±n/a nM |
|---|
| Citation |  Suebsuwong, C; Dai, B; Pinkas, DM; Duddupudi, AL; Li, L; Bufton, JC; Schlicher, L; Gyrd-Hansen, M; Hu, M; Bullock, AN; Degterev, A; Cuny, GD Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem200:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Activin receptor type-1 |
|---|
| Name: | Activin receptor type-1 |
|---|
| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 57158.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 509 |
|---|
| Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
|
|
|
|---|
| BDBM50564975 |
|---|
| n/a |
|---|
| Name | BDBM50564975 |
|---|
| Synonyms: | CHEMBL4784430 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N5O3S |
|---|
| Mol. Mass. | 453.557 |
|---|
| SMILES | COc1cc(NS(C)(=O)=O)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
