Ki Summary

Reaction Details

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Target

M-phase inducer phosphatase 2

Ligand

BDBM50129580

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_49035 (CHEMBL875900)

430.0±n/a nM

Citation

Sohn, J; Kiburz, B; Li, Z; Deng, L; Safi, A; Pirrung, MC; Rudolph, J Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones. J Med Chem46:2580-8 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

M-phase inducer phosphatase 2

Name:

M-phase inducer phosphatase 2

Synonyms:

Type:

Protein

Mol. Mass.:

64985.27

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

580

Sequence:

MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

BDBM50129580

n/a

Name

BDBM50129580

Synonyms:

3-[4,6-Dichloro-7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-2,5-dihydroxy-[1,4]benzoquinone | CHEMBL86333

Type

Small organic molecule

Emp. Form.

C19H15Cl2NO4

Mol. Mass.

392.233

SMILES

CC(C)=CCc1c(Cl)cc(Cl)c2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O |(-2.72,-7.25,;-1.19,-7.49,;-.63,-8.92,;-.23,-6.3,;-.78,-4.85,;.19,-3.66,;-.39,-2.22,;-1.93,-1.99,;.58,-1.03,;2.1,-1.27,;2.87,.07,;2.66,-2.69,;4.09,-3.24,;4.03,-4.76,;2.55,-5.16,;1.71,-3.89,;5.41,-2.45,;5.39,-.89,;4.03,-.12,;6.71,-.12,;6.67,1.42,;8.06,-.87,;8.08,-2.41,;9.44,-3.18,;6.76,-3.2,;6.76,-4.74,)|

Structure