| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50565166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2090863 (CHEMBL4772126) |
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| EC50 | 1700±n/a nM |
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| Citation |  Benchekroun, M; Ermolenko, L; Tran, MQ; Vagneux, A; Nedev, H; Delehouzé, C; Souab, M; Baratte, B; Josselin, B; Iorga, BI; Ruchaud, S; Bach, S; Al-Mourabit, A Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem201:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 75926.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13546 |
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| Residue: | 671 |
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| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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| BDBM50565166 |
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| n/a |
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| Name | BDBM50565166 |
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| Synonyms: | CHEMBL4776698 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N4O2 |
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| Mol. Mass. | 234.2545 |
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| SMILES | CCCCNc1nc2ccc(cc2[nH]1)[N+]([O-])=O |
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| Structure | 
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