| Reaction Details |
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 | Report a problem with these data |
| Target | Muscle, skeletal receptor tyrosine-protein kinase |
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| Ligand | BDBM50565310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2091394 (CHEMBL4772657) |
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| Kd | 110±n/a nM |
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| Citation |  Duan, Y; Wang, J; Zhu, S; Tu, ZC; Zhang, Z; Chan, S; Ding, K Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors. Eur J Med Chem203:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscle, skeletal receptor tyrosine-protein kinase |
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| Name: | Muscle, skeletal receptor tyrosine-protein kinase |
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| Synonyms: | MUSK | MUSK_HUMAN | Muscle, skeletal receptor tyrosine protein kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97062.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1474077 |
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| Residue: | 869 |
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| Sequence: | MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEIS
WTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMK
PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNV
QKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPV
PTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAAT
ISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELK
VVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRG
LYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPS
SSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLP
SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY
EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY
GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK
FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT
TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS
KLPADRPSFTSIHRILERMCERAEGTVSV
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| BDBM50565310 |
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| n/a |
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| Name | BDBM50565310 |
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| Synonyms: | CHEMBL4792981 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F2N4 |
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| Mol. Mass. | 376.4019 |
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| SMILES | C[C@@H](Nc1ccc2[nH]nc(\C=C\c3ccccn3)c2c1)c1cc(F)cc(F)c1 |r| |
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| Structure | 
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