| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM50130597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210504 (CHEMBL811899) |
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| Kd | 1.26±n/a nM |
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| Citation |  Yoshihara, HA; Apriletti, JW; Baxter, JD; Scanlan, TS Structural determinants of selective thyromimetics. J Med Chem46:3152-61 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50130597 |
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| n/a |
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| Name | BDBM50130597 |
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| Synonyms: | 2-Amino-3-[4-(4-hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenyl]-propionic acid | CHEMBL110335 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27NO3 |
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| Mol. Mass. | 341.444 |
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| SMILES | CC(C)c1cc(Cc2c(C)cc(C[C@H](N)C(O)=O)cc2C)ccc1O |
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| Structure | 
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