| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 1 |
|---|
| Ligand | BDBM50566212 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2094567 (CHEMBL4775830) |
|---|
| IC50 | 3600±n/a nM |
|---|
| Citation |  Rowlands, RA; Chen, Q; Bouley, RA; Avramova, LV; Tesmer, JJG; White, AD Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem64:566-585 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-adrenergic receptor kinase 1 |
|---|
| Name: | Beta-adrenergic receptor kinase 1 |
|---|
| Synonyms: | ADRBK1 | ARBK1_BOVIN | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein-coupled receptor kinase 2 | GRK2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 79654.58 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_113511 |
|---|
| Residue: | 689 |
|---|
| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC
SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLIQRGSANGL
|
|
|
|---|
| BDBM50566212 |
|---|
| n/a |
|---|
| Name | BDBM50566212 |
|---|
| Synonyms: | CHEMBL4780266 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H26BrFN4O3 |
|---|
| Mol. Mass. | 553.423 |
|---|
| SMILES | C[C@H](Cc1ccc(F)cc1)NC(=O)c1ccc2NC(=O)\C(=C/c3[nH]c(C)c(NC(=O)CBr)c3C)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
