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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50130973 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_51266 | ||
| Ki | 4±n/a nM | ||
| Citation |  Hodgetts, KJ; Yoon, T; Huang, J; Gulianello, M; Kieltyka, A; Primus, R; Brodbeck, R; De Lombaert, S; Doller, D 2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists. Bioorg Med Chem Lett13:2497-500 (2003) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50130973 | |||
| n/a | |||
| Name | BDBM50130973 | ||
| Synonyms: | 5-Dipropylamino-3,6-diethyl-2-(2-methoxy-4,6-dimethyl-phenyl)-3H-pyrimidin-4-one | CHEMBL313479 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H35N3O2 | ||
| Mol. Mass. | 385.5429 | ||
| SMILES | CCCN(CCC)c1c(CC)nc(-c2c(C)cc(C)cc2OC)n(CC)c1=O |(.82,4.8,;.82,3.26,;-.51,2.49,;-.51,.95,;-1.84,.18,;-1.84,-1.36,;-3.17,-2.13,;.82,.18,;.82,-1.36,;-.51,-2.13,;-.51,-3.67,;2.15,-2.13,;3.48,-1.36,;4.83,-2.13,;4.81,-3.67,;3.48,-4.44,;6.16,-4.44,;7.49,-3.67,;8.83,-4.44,;7.47,-2.12,;6.14,-1.36,;6.16,.2,;7.47,.96,;3.48,.18,;4.81,.96,;4.81,2.5,;2.15,.95,;2.15,2.49,)| | ||
| Structure | 
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