| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 6 |
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| Ligand | BDBM50566937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102025 (CHEMBL4810421) |
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| IC50 | 70±n/a nM |
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| Citation |  Uehling, DE; Joseph, B; Chung, KC; Zhang, AX; Ler, S; Prakesch, MA; Poda, G; Grouleff, J; Aman, A; Kiyota, T; Leung-Hagesteijn, C; Konda, JD; Marcellus, R; Griffin, C; Subramaniam, R; Abibi, A; Strathdee, CA; Isaac, MB; Al-Awar, R; Tiedemann, RE Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. J Med Chem64:11129-11147 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-coupled receptor kinase 6 |
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| Name: | G protein-coupled receptor kinase 6 |
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| Synonyms: | GPRK6 | GRK6 | GRK6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66001.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_793895 |
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| Residue: | 576 |
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| Sequence: | MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
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| BDBM50566937 |
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| n/a |
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| Name | BDBM50566937 |
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| Synonyms: | CHEMBL4850937 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN6 |
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| Mol. Mass. | 392.885 |
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| SMILES | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cc3)nc3ccccc23)n[nH]1 |r| |
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| Structure | 
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