| Reaction Details |
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 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 2 |
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| Ligand | BDBM50567047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102252 (CHEMBL4810648) |
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| Kd | 1200±n/a nM |
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| Citation |  Henderson, SH; Sorrell, F; Bennett, J; Fedorov, O; Hanley, MT; Godoi, PH; Ruela de Sousa, R; Robinson, S; Ashall-Kelly, A; Hopkins Navratilova, I; Walter, DS; Elkins, JM; Ward, SE Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem64:11709-11728 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeodomain-interacting protein kinase 2 |
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| Name: | Homeodomain-interacting protein kinase 2 |
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| Synonyms: | HIPK2 | HIPK2_HUMAN | Homeodomain-interacting protein kinase 2 | Homeodomain-interacting protein kinase 2 (HIPK2) |
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| Type: | Protein |
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| Mol. Mass.: | 131001.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H2X6 |
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| Residue: | 1198 |
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| Sequence: | MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
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| BDBM50567047 |
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| n/a |
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| Name | BDBM50567047 |
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| Synonyms: | CHEMBL4848254 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N6 |
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| Mol. Mass. | 240.2639 |
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| SMILES | CN(C)c1nccc(n1)-c1cnn2ncccc12 |
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| Structure | 
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