| Reaction Details |
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 | Report a problem with these data |
| Target | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Ligand | BDBM50567047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102256 (CHEMBL4810652) |
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| Kd | 10000±n/a nM |
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| Citation |  Henderson, SH; Sorrell, F; Bennett, J; Fedorov, O; Hanley, MT; Godoi, PH; Ruela de Sousa, R; Robinson, S; Ashall-Kelly, A; Hopkins Navratilova, I; Walter, DS; Elkins, JM; Ward, SE Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem64:11709-11728 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| STE20/SPS1-related proline-alanine-rich protein kinase |
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| Name: | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Synonyms: | DCHT | SPAK | STK39 | STK39_HUMAN | Serine/threonine-protein kinase 39 | Ste-20-related kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59471.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774551 |
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| Residue: | 545 |
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| Sequence: | MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICR
DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN
VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGL
DYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMA
PEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDK
EMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQR
AKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSAS
TIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTAD
GVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFA
QLSVS
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| BDBM50567047 |
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| n/a |
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| Name | BDBM50567047 |
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| Synonyms: | CHEMBL4848254 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N6 |
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| Mol. Mass. | 240.2639 |
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| SMILES | CN(C)c1nccc(n1)-c1cnn2ncccc12 |
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| Structure | 
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