| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50567205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2102484 (CHEMBL4810880) |
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| IC50 | >10000±n/a nM |
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| Citation |  Butler, KJ; Castro, AA; Dwyer, TS; Hardwick, LM; Iacino, MC; Manore, SG; Mays, KM; McGlade, CA; Hair, LN; Parker, EW; Smith, MR; Turnow, MT; Wilson, MR; Woodson, SR; Cotham, WE; Walla, MD; Hurlbert, JC; Christian Grattan, T Design, synthesis and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42521.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYA1 |
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| Residue: | 384 |
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| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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| BDBM50567205 |
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| n/a |
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| Name | BDBM50567205 |
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| Synonyms: | CHEMBL4858010 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O2 |
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| Mol. Mass. | 370.4039 |
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| SMILES | COc1ccccc1\C=N\NC(=O)c1cc([nH]n1)-c1ccc2ccccc2c1 |
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| Structure | 
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