Reaction Details |
| Report a problem with these data |
Target | Dual specificity mitogen-activated protein kinase kinase 4 |
---|
Ligand | BDBM50567689 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2103768 (CHEMBL4812271) |
---|
IC50 | 29±n/a nM |
---|
Citation | Pfaffenrot, B; Klövekorn, P; Juchum, M; Selig, R; Albrecht, W; Zender, L; Laufer, SA Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration. Eur J Med Chem218:0 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dual specificity mitogen-activated protein kinase kinase 4 |
---|
Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
Synonyms: | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1 |
Type: | PROTEIN |
Mol. Mass.: | 44294.29 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1460558 |
Residue: | 399 |
Sequence: | MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
|
|
|
BDBM50567689 |
---|
n/a |
---|
Name | BDBM50567689 |
Synonyms: | CHEMBL4790247 |
Type | Small organic molecule |
Emp. Form. | C24H21F2N5O6S2 |
Mol. Mass. | 577.58 |
SMILES | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(=O)(=O)NC(C)=O)c1F |
Structure |
|