Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50097889 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_69845 (CHEMBL681895) |
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Ki | 400±n/a nM |
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Citation | Szajnman, SH; Montalvetti, A; Wang, Y; Docampo, R; Rodriguez, JB Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. Bioorg Med Chem Lett13:3231-5 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50097889 |
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n/a |
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Name | BDBM50097889 |
Synonyms: | (1-Hydroxy-1-phosphono-hexyl)-phosphonic acid | 1-hydroxyhexane-1,1-diyldiphosphonic acid | CHEMBL299988 |
Type | Small organic molecule |
Emp. Form. | C6H16O7P2 |
Mol. Mass. | 262.1346 |
SMILES | CCCCCC(O)(P(O)(O)=O)P(O)(O)=O |
Structure |
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