| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 7 |
|---|
| Ligand | BDBM50568247 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2104904 (CHEMBL4813407) |
|---|
| IC50 | 6100±n/a nM |
|---|
| Citation |  El-Awady, R; Saleh, E; Hamoudi, R; Ramadan, WS; Mazitschek, R; Nael, MA; Elokely, KM; Abou-Gharbia, M; Childers, WE; Srinivasulu, V; Aloum, L; Menon, V; Al-Tel, TH Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents. Bioorg Med Chem42:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 7 |
|---|
| Name: | Histone deacetylase 7 |
|---|
| Synonyms: | HD7 | HDAC7 | HDAC7A | HDAC7_HUMAN | Histone acetylase 7 (HDAC7) | Histone deacetylase 7A | Human HDAC7 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 102942.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8WUI4 |
|---|
| Residue: | 952 |
|---|
| Sequence: | MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVG
PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPL
ETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKE
SAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSV
APFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGG
TLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEP
LPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVV
DDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRP
LSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSR
HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD
NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG
FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQ
DPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRI
VVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALE
GGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
LASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
|
|
|
|---|
| BDBM50568247 |
|---|
| n/a |
|---|
| Name | BDBM50568247 |
|---|
| Synonyms: | CHEMBL4854201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H24FN5O |
|---|
| Mol. Mass. | 417.4787 |
|---|
| SMILES | CC(C)(C)Nc1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1ccc(F)cc1N |
|---|
| Structure | 
|
|---|
Search and Browse
