| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C beta type |
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| Ligand | BDBM50133236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_160469 (CHEMBL761765) |
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| Ki | 1.4±n/a nM |
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| Citation |  Sridhar, J; Wei, ZL; Nowak, I; Lewin, NE; Ayres, JA; Pearce, LV; Blumberg, PM; Kozikowski, AP New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem46:4196-204 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C beta type |
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| Name: | Protein kinase C beta type |
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| Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76873.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
|
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| Residue: | 671 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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| BDBM50133236 |
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| n/a |
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| Name | BDBM50133236 |
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| Synonyms: | CHEMBL337834 | Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopropyl-1-methyl-3-(S)-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl)-amide ((S)-5-hydroxymethyl-2-isopropyl-1-(S)-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-9-yl)-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C44H68N6O6 |
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| Mol. Mass. | 777.0473 |
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| SMILES | CC(C)[C@@H]1N(C)c2ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc3ccc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c4c3)cc2C[C@@H](CO)NC1=O |
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| Structure | 
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