| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lanosterol synthase |
|---|
| Ligand | BDBM50133285 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_149035 (CHEMBL874645) |
|---|
| IC50 | 49±n/a nM |
|---|
| Citation |  Hinshaw, JC; Suh, DY; Garnier, P; Buckner, FS; Eastman, RT; Matsuda, SP; Joubert, BM; Coppens, I; Joiner, KA; Merali, S; Nash, TE; Prestwich, GD Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem46:4240-3 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lanosterol synthase |
|---|
| Name: | Lanosterol synthase |
|---|
| Synonyms: | LSS_RAT | Lss | Osc |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 83302.12 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_12083 |
|---|
| Residue: | 733 |
|---|
| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
|
|
|
|---|
| BDBM50133285 |
|---|
| n/a |
|---|
| Name | BDBM50133285 |
|---|
| Synonyms: | (E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoyl)-phenoxy]-hexyl}-methyl-ammonium; | CHEMBL135109 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28ClFNO2 |
|---|
| Mol. Mass. | 404.925 |
|---|
| SMILES | C[NH+](CCCCCCOc1ccc(C(=O)c2ccc(Cl)cc2)c(F)c1)CC=C |
|---|
| Structure | 
|
|---|
Search and Browse
