Ki Summary

Reaction Details

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Target

Adenosine receptor A3

Ligand

BDBM50051234

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_29890 (CHEMBL641961)

2.03±n/a nM

Citation

Pastorin, G; Da Ros, T; Spalluto, G; Deflorian, F; Moro, S; Cacciari, B; Baraldi, PG; Gessi, S; Varani, K; Borea, PA Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation. J Med Chem46:4287-96 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A3

Name:

Adenosine receptor A3

Synonyms:

A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36197.32

Organism:

Homo sapiens (Human)

Description:

P0DMS8

Residue:

318

Sequence:

MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

BDBM50051234

n/a

Name

BDBM50051234

Synonyms:

2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine | 2-Furan-2-yl-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine | CHEMBL16867 | N-[2-Furan-2-yl-8-(3-phenyl-propyl)-2,8-dihydro-3H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-2-phenoxy-acetamide

Type

Small organic molecule

Emp. Form.

C18H15N7O

Mol. Mass.

345.358

SMILES

Nc1nc2nn(CCc3ccccc3)cc2c2nc(nn12)-c1ccco1

Structure