| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Ligand | BDBM50396483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2105912 (CHEMBL4814587) |
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| Kd | 8.2±n/a nM |
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| Citation |  Klövekorn, P; Pfaffenrot, B; Juchum, M; Selig, R; Albrecht, W; Zender, L; Laufer, SA From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4). Eur J Med Chem210:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 4 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Synonyms: | C-JUN N-terminal kinase kinase 1 | JNK kinase 1 | JNK-activating kinase 1 | JNKK 1 | Jnkk1 | MAP kinase kinase 4 | MAPK/ERK kinase 4 | MAPKK 4 | MP2K4_MOUSE | Map2k4 | Mek4 | Mkk4 | Prkmk4 | SAPK/ERK kinase 1 | Sek1 | Serk1 | Skk1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44120.14 |
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| Organism: | Mus musculus |
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| Description: | EBI_11048 |
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| Residue: | 397 |
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| Sequence: | MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLN
PNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK
PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS
TSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGN
IKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT
GRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELL
KHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
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| BDBM50396483 |
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| n/a |
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| Name | BDBM50396483 |
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| Synonyms: | PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18ClF2N3O3S |
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| Mol. Mass. | 489.922 |
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| SMILES | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F |
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| Structure | 
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