Reaction Details |
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Target | Activin receptor type-1 |
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Ligand | BDBM4077 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2107053 (CHEMBL4815728) |
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IC50 | 4.0±n/a nM |
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Citation | Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1 |
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Name: | Activin receptor type-1 |
Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
Type: | n/a |
Mol. Mass.: | 57158.32 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 509 |
Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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BDBM4077 |
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n/a |
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Name | BDBM4077 |
Synonyms: | 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethyl-6-phenyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one | 2-[4-(2-Diethylaminoethoxy)phenylamino]-8-ethyl-6-phenyl-8H-pyrido[2,3-d]pyrimidin-7-one | pyrido[2,3-d]pyrimidin-7-one deriv. 54 |
Type | Small organic molecule |
Emp. Form. | C27H31N5O2 |
Mol. Mass. | 457.5673 |
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1 |
Structure |
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