Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Ligand | BDBM50568931 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
IC50 | 13±n/a nM | ||
Citation | Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nucleotide-binding oligomerization domain-containing protein 2 | |||
Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 115287.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1454053 | ||
Residue: | 1040 | ||
Sequence: |
| ||
BDBM50568931 | |||
n/a | |||
Name | BDBM50568931 | ||
Synonyms: | CHEMBL4859716 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H31Cl2N5O3 | ||
Mol. Mass. | 556.483 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 |(30.47,-43.28,;31.8,-42.51,;33.14,-43.28,;33.14,-44.82,;31.81,-45.59,;34.47,-42.51,;35.81,-43.28,;37.14,-42.51,;38.47,-43.28,;38.47,-44.83,;39.81,-45.6,;41.14,-44.83,;42.48,-45.59,;43.81,-44.82,;43.8,-43.29,;45.12,-42.51,;46.47,-43.28,;47.8,-42.51,;49.14,-43.29,;50.47,-42.52,;51.8,-43.3,;51.79,-44.84,;53.14,-42.54,;53.15,-41,;51.81,-40.22,;50.48,-40.99,;49.14,-40.22,;49.13,-44.83,;50.46,-45.61,;47.79,-45.6,;47.78,-47.14,;46.44,-47.9,;46.44,-49.44,;45.1,-50.2,;46.46,-44.82,;45.14,-45.59,;41.14,-43.28,;39.8,-42.51,)| | ||
Structure |