Reaction Details | |||
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Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Ligand | BDBM50568932 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
IC50 | 9.0±n/a nM | ||
Citation | Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nucleotide-binding oligomerization domain-containing protein 2 | |||
Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 115287.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1454053 | ||
Residue: | 1040 | ||
Sequence: |
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BDBM50568932 | |||
n/a | |||
Name | BDBM50568932 | ||
Synonyms: | CHEMBL4858463 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H31Cl2N5O2 | ||
Mol. Mass. | 588.527 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 |(58.86,-44.1,;60.19,-43.33,;61.53,-44.1,;61.53,-45.64,;60.19,-46.41,;62.86,-43.33,;64.19,-44.1,;65.53,-43.33,;66.86,-44.1,;66.86,-45.64,;68.19,-46.41,;69.53,-45.64,;70.87,-46.41,;72.2,-45.64,;72.19,-44.1,;73.51,-43.33,;74.86,-44.1,;76.19,-43.32,;77.53,-44.1,;78.86,-43.34,;78.86,-41.81,;77.53,-41.04,;80.2,-41.04,;81.54,-41.82,;81.53,-43.36,;80.19,-44.12,;80.18,-45.66,;77.52,-45.65,;78.85,-46.43,;76.18,-46.41,;76.17,-47.95,;74.83,-48.72,;73.51,-47.93,;72.17,-48.69,;72.17,-50.24,;73.51,-51.01,;74.84,-50.25,;74.85,-45.64,;73.53,-46.41,;69.53,-44.09,;68.19,-43.33,)| | ||
Structure |