Reaction Details | |||
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Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Ligand | BDBM50568933 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
IC50 | 3.0±n/a nM | ||
Citation | Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nucleotide-binding oligomerization domain-containing protein 2 | |||
Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 115287.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1454053 | ||
Residue: | 1040 | ||
Sequence: |
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BDBM50568933 | |||
n/a | |||
Name | BDBM50568933 | ||
Synonyms: | CHEMBL4847211 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H33Cl2N5O2 | ||
Mol. Mass. | 554.511 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 |(1.53,-6.82,;2.86,-6.05,;4.2,-6.82,;4.2,-8.36,;2.86,-9.13,;5.53,-6.05,;6.87,-6.82,;8.2,-6.05,;9.53,-6.82,;9.53,-8.37,;10.86,-9.14,;12.2,-8.36,;13.54,-9.13,;14.87,-8.36,;14.86,-6.82,;16.18,-6.05,;17.53,-6.82,;18.86,-6.04,;20.2,-6.83,;21.53,-6.06,;21.54,-4.53,;20.2,-3.76,;22.87,-3.76,;24.21,-4.54,;24.2,-6.08,;22.86,-6.84,;22.85,-8.38,;20.19,-8.37,;21.52,-9.15,;18.85,-9.13,;18.84,-10.67,;17.5,-11.44,;16.17,-10.66,;17.5,-12.98,;17.52,-8.36,;16.2,-9.13,;12.2,-6.81,;10.86,-6.05,)| | ||
Structure |