Reaction Details | |||
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Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Ligand | BDBM50568942 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
IC50 | 94±n/a nM | ||
Citation | Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Nucleotide-binding oligomerization domain-containing protein 2 | |||
Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 115287.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1454053 | ||
Residue: | 1040 | ||
Sequence: |
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BDBM50568942 | |||
n/a | |||
Name | BDBM50568942 | ||
Synonyms: | CHEMBL4874031 | ||
Type | Small organic molecule | ||
Emp. Form. | C33H33Cl2N5O4S | ||
Mol. Mass. | 666.617 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccc(cc4)S(C)(=O)=O)c3n2)cc1 |(54.68,-6.89,;56.02,-6.11,;57.35,-6.88,;57.35,-8.42,;56.02,-9.19,;58.68,-6.11,;60.02,-6.88,;61.35,-6.11,;62.69,-6.88,;62.68,-8.43,;64.02,-9.2,;65.36,-8.43,;66.69,-9.19,;68.02,-8.42,;68.01,-6.89,;69.34,-6.11,;70.68,-6.88,;72.01,-6.11,;73.35,-6.89,;74.69,-6.12,;74.69,-4.59,;73.36,-3.82,;76.02,-3.82,;77.36,-4.6,;77.35,-6.14,;76.01,-6.9,;76.01,-8.44,;73.34,-8.43,;74.67,-9.21,;72,-9.2,;72,-10.74,;70.66,-11.5,;69.33,-10.72,;68,-11.48,;67.99,-13.02,;69.33,-13.8,;70.66,-13.03,;66.65,-13.78,;65.32,-13.01,;67.41,-15.11,;65.88,-15.11,;70.68,-8.42,;69.35,-9.19,;65.35,-6.88,;64.01,-6.11,)| | ||
Structure |