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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
| Ligand | BDBM50568935 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
| IC50 | 136±n/a nM | ||
| Citation |  Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nucleotide-binding oligomerization domain-containing protein 2 | |||
| Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
| Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 115287.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1454053 | ||
| Residue: | 1040 | ||
| Sequence: |
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| BDBM50568935 | |||
| n/a | |||
| Name | BDBM50568935 | ||
| Synonyms: | CHEMBL4868894 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16Cl2N4O3S | ||
| Mol. Mass. | 475.348 | ||
| SMILES | Cn1c2nc(Nc3ccc(cc3)S(C)(=O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(13.36,-27.74,;13.37,-26.2,;12.04,-25.43,;10.72,-26.2,;9.39,-25.43,;8.06,-26.2,;6.72,-25.43,;5.39,-26.2,;4.05,-25.43,;4.06,-23.89,;5.38,-23.12,;6.72,-23.88,;2.72,-23.12,;1.39,-23.89,;1.94,-21.78,;3.49,-21.78,;9.38,-23.89,;10.7,-23.12,;12.05,-23.89,;13.38,-23.11,;14.72,-23.9,;16.05,-23.13,;16.05,-21.6,;14.72,-20.83,;17.38,-20.83,;18.72,-21.61,;18.71,-23.15,;17.38,-23.91,;17.37,-25.45,;14.71,-25.44,;16.04,-26.22,)| | ||
| Structure | 
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