Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nucleotide-binding oligomerization domain-containing protein 2 | ||
| Ligand | BDBM50568936 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2107055 (CHEMBL4815730) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Nikhar, S; Siokas, I; Schlicher, L; Lee, S; Gyrd-Hansen, M; Degterev, A; Cuny, GD Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem215:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nucleotide-binding oligomerization domain-containing protein 2 | |||
| Name: | Nucleotide-binding oligomerization domain-containing protein 2 | ||
| Synonyms: | CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 115287.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1454053 | ||
| Residue: | 1040 | ||
| Sequence: |
| ||
| BDBM50568936 | |||
| n/a | |||
| Name | BDBM50568936 | ||
| Synonyms: | CHEMBL4864600 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16Cl2N4O3S | ||
| Mol. Mass. | 475.348 | ||
| SMILES | Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(31.78,-28.56,;31.78,-27.03,;30.46,-26.25,;29.13,-27.02,;27.81,-26.25,;26.47,-27.02,;25.14,-26.26,;23.8,-27.03,;22.47,-26.26,;22.47,-24.71,;23.8,-23.94,;25.13,-24.71,;23.79,-22.4,;25.13,-21.63,;22.3,-21.99,;23.39,-20.9,;27.79,-24.72,;29.12,-23.94,;30.46,-24.71,;31.8,-23.94,;33.13,-24.72,;34.47,-23.96,;34.47,-22.42,;33.14,-21.65,;35.8,-21.65,;37.14,-22.43,;37.13,-23.97,;35.79,-24.73,;35.78,-26.27,;33.13,-26.26,;34.45,-27.04,)| | ||
| Structure | 
| ||